Normally the unconjugated bilirubin makes up 70% to 85% of the total bilirubin. Unconjugated bilirubin is protein-bound. Routine exams generally measure total bilirubin, which may then be broken down into unconjugated and conjugated. Unconjugated results may not be reported by all laboratories. Unconjugated bilirubin is fat soluble however conjugated bilirubin is water-soluble and hence can be excreted through kidneys. An increase in the level of conjugated bilirubin means an indication towards hepatobiliary disease. Unconjugated bilirubin generally reacts slowly in the absence of an accelerator namely ethanol. In order to calculate indirect bilirubin the formula of Total bilirubin - Direct bilirubin is used. The unconjugated bilirubin has high molecular weight and cannot be filtered through the kidney. The conjugated bilirubin is present in bile, while the unconjugated bilirubin is not present in bile. The conjugated bilirubin is normally not present in urine, but appears in high plasma concentrations. The unconjugated bilirubin is not present in urine. Conjugated (Direct): Bilirubin is converted from unconjugated to conjugated bilirubin in the liver. This happens when sugar attaches to the unconjugated bilirubin. The unconjugated bilirubin turns into bile and enters the small intestines. It is eventually eliminated through a person's stool. This molecule is water soluble. Conjugated (Direct): Bilirubin is converted from unconjugated to conjugated bilirubin in the liver. This happens when sugar attaches to the unconjugated bilirubin. The unconjugated bilirubin turns into bile and enters the small intestines. It is eventually eliminated through a person's stool. This molecule is water soluble. What is the difference between Conjugated and Unconjugated Bilirubin? • Unconjugated bilirubin is water insoluble while conjugated bilirubin is water-soluble. • Unconjugated bilirubin forms in the reticuloendothelial cells while liver forms conjugated bilirubin. Conjugated (Direct): Bilirubin is converted from unconjugated to conjugated bilirubin in the liver. This happens when sugar attaches to the unconjugated bilirubin. The unconjugated bilirubin turns into bile and enters the small intestines. It is eventually eliminated through a person's stool. Unconjugated bilirubin is a waste product that results from the process of breaking down old red blood cells. Unconjugated bilirubin is the unrefined or raw bilirubin present in the body. Sometimes called free bilirubin or indirect bilirubin, it is a waste product that results from the process used to break down old red blood cells. Conjugated bilirubin (direct bilirubin) is not reabsorbed from the proximal intestine as mentioned above; in comparison, unconjugated bilirubin is partially reabsorbed across the lipid membrane of the small intestinal epithelium and undergoes enterohepatic circulation. Within the proximal small intestine, there is no additional metabolism of bilirubin, and very little deconjugation takes place. In stark contrast, when the conjugated bilirubin reaches the distal ileum and colon, it is rapidly When old red cells pass through the spleen, macrophages eat them up and break down the heme into unconjugated bilirubin (which is not water soluble). The unconjugated bilirubin is then sent to the liver, which conjugates the bilirubin with glucuronic acid, making it soluble in water. Most of this conjugated bilirubin goes into the bile and out into the small intestine. (An interesting aside: some of the conjugated bilirubin remains in the large intestine and is metabolized into
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This video screencast was created with Doceri on an iPad. Doceri is free in the iTunes app store. Learn more at http://www.doceri.com http://www.handwrittentutorials.com - This tutorial is the second of the Bilirubin series. It explains the process of Bilirubin Metabolism in the liver. This... In the liver, bilirubin is conjugated with glucuronic acid by the enzyme glucuronyltransferase, making it soluble in water: the conjugated version is the mai... https://www.facebook.com/ArmandoHasudunganSupport me: http://www.patreon.com/armandoInstagram:http://instagram.com/armandohasudunganTwitter:https://twitter.c... How does conjugated bilirubin enter the blood? Unconjugated bilirubin is not water-soluble and so is not excreted in the urine.The difference between unconjugated and conjugated bilirubin is that unconjug... conjugated vs unconjugated bilirubindifference between conjugated and unconjugated bilirubin يتناول الفيديو شرح المسار الطبيعي للصفراء المباشرة وغير المباشرة في الدم Click on this link to subscribe https://www.youtube.com ... http://www.handwrittentutorials.com - This tutorial is the first of the Bilirubin series. It explains the Bilirubin Pathway from the destruction of Red Blood... GET LECTURE HANDOUTS and other DOWNLOADABLE CONTENT FROM THIS VIDEOSUPPORT US ON PATREON OR JOIN HERE ON YOUTUBE.https://www.patreon.com/medsimplifiedBilirub...
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